Rb275-270108-WS

A synthetic peptide from human ATG16L1 conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in mouse and rat.

ATG16L1_HUMAN
ATG16L1_ORANGUTAN

ATG16L1, APG16L, IBD10, WDR30, APG16L, ATG16L, FLJ00045, FLJ10035, FLJ10828, FLJ22677

FUNCTION: Plays an essential role in autophagy.
SUBUNIT: Homooligomer. Interacts with ATG5. Part of either the minor and major complexes respectively composed of 4 sets of ATG12-ATG5 and ATG16L1 (400 kDa) or 8 sets of ATG12-ATG5 and ATG16L1 (800 kDa).
SUBCELLULAR LOCATION: Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note: Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5.
DISEASE: Genetic variations in ATG16L1 are associated with susceptibility to inflammatory bowel disease type 10 (IBD10). IBD is characterized by a chronic relapsing intestinal inflammation. IBD is subdivided into Crohn disease (CD) and ulcerative colitis phenotypes. IBD10 individuals show the phenotype characteristic to CD. It may involve any part of the gastrointestinal tract, but most frequently the terminal ileum and colon. CD is commonly classified as autoimmune disease.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Van Limbergen J, et al. Inflamm. Bowel Dis. 14 (3), 338-346(2008).
2. Perricone C, et al. Gastroenterology 134 (1), 368-370(2008).
3. Massey D.C et al. Autophagy 3 (6), 649-651(2007).

For research use only

	Code Product Name OSA00046W Sheep antibody to ATG16L1

150 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. Use at a dilution of 1 : 100 to 1 : 2000. The optimal dilution should be determined by the end user.

Specific for ATG16L1.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet