Rb1247-051209-WS

A synthetic peptide from aa region 650-700 of mouse KCNQ3 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat.

KCNQ3_MOUSE
KCNQ3_RAT

Potassium voltage-gated channel subfamily KQT member 3, Voltage-gated potassium channel subunit Kv7.3, Potassium channel subunit alpha KvLQT3, KQT-like 3

Function: Probably important in the regulation of neuronal excitability. Associates with KCNQ2 or KCNQ5 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs.
Tissue specificity: Predominantly expressed in brain. Expressed in brain and sympathetic ganglia. In brain, expressed in cortex, hippocampus and at much lower levels in cerebellum. In sympathetic ganglia, expressed at approximately equal levels in both superior cervical ganglia and prevertebral ganglia.
Subcellular location: Membrane; Multi-pass membrane protein.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Munton R.P, et al. Mol. Cell. Proteomics 6:283-293(2007)
2. Sweet S.M, et al. Mol. Cell. Proteomics 8:904-912(2009)

For research use only

	Code Product Name OSP00099W Rabbit antibody to KCNQ3 (750-800) OSK00071W Rabbit antibody to KCNQ3 (60-120)

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 200 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for KCNQ3.

Mouse, rat. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

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