A synthetic peptide from mouse M6PR conjugated to blue carrier protein was used as the antigen.
CD Man-6-P receptor, CD-MPR, 46 kDa mannose 6-phosphate receptor, MPR 46, Cation-dependent mannose-6-phosphate receptor, M6pr, 46mpr
FUNCTION: Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex.
SUBUNIT: Homodimer. Binds GGA1, GGA2 and GGA3.
SUBCELLULAR LOCATION: Lysosome membrane; Single-pass type I membrane protein.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Ludwig T, et al. J. Biol. Chem. 267:12211-12219(1992).
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 3000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for M6PR.
Mouse, rat, human, marmoset. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.