Sh72-290608-WS

A synthetic peptide from aa region 320-370 of rabbit TRPV6 conjugated to an immunogenic carrier protein was used as the antigen.
The location of the epitope is highlighted in green.

Transient receptor potential cation channel subfamily V member 6, TrpV6, Epithelial calcium channel 2, ECaC2, Calcium transport protein 1, CaT1, Trpv6 transient receptor potential cation channel, subfamily V, member 6, CaT1, Ecac2, Otrpc3

FUNCTION: Calcium selective cation channel probably involved in Ca(2+) uptake in various tissues, including Ca(2+) reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca(2+)-dependent and a slower Ca(2+)-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg(2+) in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
SUBUNIT: Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5, heterotetramer. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in duodenum, proximal jejunum, cecum, and colon.
SIMILARITY: Belongs to the transient receptor family, TrpV subfamily.
SIMILARITY: Contains 5 ANK repeats.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Peng J.-B, et al. J. Biol. Chem. 274:22739-22746(1999).
2. Yue L., et al. Nature 410:705-709(2001).
3. Huang,Y, et al. J. Neurosci. 27 (3), 449-458 (2007).

For research use only

	Code Product Name

100 µl

Unconjugated antibody

Sheep

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Specific for TRPV6.

Rabbit. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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