A synthetic peptide from aa region 150-200 of human COPD conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat, mouse and xenopus.
Archain, ARCN1, Coatomer subunit delta, Delta-coat protein, Delta-COP
FUNCTION: The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.
SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, COPI-coated vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: The coatomer is cytoplasmic or polymerized on the cytoplasmic side of the Golgi, as well as on the vesicles/buds originating from it.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Radice P, et al. Genomics 26:101-106(1995).
2. Faulstich D, et al. J. Cell Biol. 135:53-61(1996).
For research use only
NZ white rabbit
IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user.
Specific for COPD.
Human, rat, mouse. Other species not yet tested.
Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.