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Code
OSM00029W
$240USD
ID Tag
Rb278-270108-WS
Immunogen
A synthetic peptide from human microtubule-associated proteins 1A/1B light chain 3A (MAP1LC3A, MAP1A/MAP1B LC3 A) conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in rat, mouse and bovine.
Accession
Also known
MAP1A/MAP1B LC3 A, MAP1A/1B light chain 3 A, MAP1 light chain 3-like protein 1, Microtubule-associated protein 1 light chain 3 alpha, Autophagy-related protein LC3 A
Autophagy-related ubiquitin-like modifier LC3 A, MAP1ALC3, MAP1BLC3, MAP1LC3A
Target
MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene.
This protein is probably involved in formation of autophagosomal vacuoles.
SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note: LC3-II binds to the autophagic membranes.
TISSUE SPECIFICITY: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
This protein is probably involved in formation of autophagosomal vacuoles.
SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note: LC3-II binds to the autophagic membranes.
TISSUE SPECIFICITY: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Taylor M.P, et al. J. Virol. 81 (22), 12543-12553(2007).
2. Pankiv S, et al. J. Biol. Chem. 282 (33), 24131-24145(2007).
3. Lunemann J.D, et al. Autophagy 3 (4), 384-386(2007).
2. Pankiv S, et al. J. Biol. Chem. 282 (33), 24131-24145(2007).
3. Lunemann J.D, et al. Autophagy 3 (4), 384-386(2007).
Limitation
For research use only
Related
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Code
OSM00029W
$240USD
Unit size
150 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. Use at a dilution of 1 : 200 to 1 : 2000. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for MAP1LC3A.
Spcs X-react.
Human, mouse and rat. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSM00029W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
Code
OSM00029W
$240USD
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WB on human neutrophil lysate using Rabbit antibody to microtubule-associated protein 1 light chain 3 alpha (MAP1LC3A, MAP1ALC3, MAP1BLC3, MAP1A/MAP1B LC3 A): whole serum (OSM00029W) at a dilution of 1 : 100. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band. |
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