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Code
OSR00248W
$240USD
ID Tag
Rb291-270108-WS
Immunogen
A synthetic peptide from human RGS19 conjugated to blue carrier protein has been used as the antigen. The peptide is homologous in rat and mouse.
Accession
Also known
RGS19, G-alpha-interacting protein, GAIP, GNAI3IP, RGSGAIP
Target
G proteins mediate a number of cellular processes. The protein encoded by this gene belongs to the RGS (regulators of G-protein signaling) family and specifically interacts with G protein, GAI3. This protein is a guanosine triphosphatase-activating protein that functions to down-regulate Galpha i/Galpha q-linked signaling. Alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
TISSUE SPECIFICITY: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
FUNCTION: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
SUBCELLULAR LOCATION: Membrane; Lipid-anchor.
TISSUE SPECIFICITY: Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. de Vries L, et al. Proc. Natl. Acad. Sci. U.S.A.
Limitation
For research use only
Code
OSR00248W
$240USD
Unit size
150 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. Use at a dilution of 1:1000 to 1: 3000. The optimal dilution should be determined by the end user.
Specificity
Specific for RGS19.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
- Click to see the eLab Book
Code
OSR00248W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
Code
OSR00248W
$240USD
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WB on mouse tissue lysates. Blocking with 0.5% LFDM for 30 min at RT; Primary antibody used at 1:3000 dilution incubated overnight at 4C. Click on eLAB BOOK tab to see the details. |
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Rabbit antibody to RGS19
