MRGPRX1 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSR00109W

$240USD

ID Tag

Rb147-281007-WS

Immunogen

A synthetic peptide from human Mas-related G-protein coupled receptor member X1, X3 and X4 (MRGPRX1, MRGPRX3, MRGPRX4) conjugated to blue carrier protein was used as the antigen.

Accession

MRGPRX1_HUMAN
MRGPRX3_HUMAN
MRGPRX4_HUMAN
MRGPRX3_MACMU

Also known

Mas-related G-protein coupled receptor member X1, X3, X4; Sensory neuron-specific G-protein coupled receptor 3/4, MRGX1, SNSR3, SNSR4, GPCR, MAS-related GPR, member X1, MRGX3, SNSR1, SNSR2, Sensory neuron-specific G-protein coupled receptor 1/2, Sensory neuron-specific G-protein coupled receptor 5/6, MRGX4, SNSR5, SNSR6, MAS-related GPR, member X3; MRGPRX4, MRGPRX3, MRGPRX1

Target

FUNCTION: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Uniquely localized in a subset of small dorsal root and trigeminal sensory neurons.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Dong X, et al. Cell 106:619-632(2001).

Limitation

For research use only

Code

OSR00109W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for MRGPRX1, 3 and 4.

Spcs X-react.

Human. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSR00109W