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Code
OSR00100W
$240USD
ID Tag
Rb105-281007-WS
Immunogen
A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit delta (SCNN1D, SCNED, Delta-ENaC) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Epithelial Na(+) channel subunit delta, delta-ENaC, nonvoltage-gated sodium channel 1 subunit delta, SCNED, delta-NaCH, dNaCh, ENaCdelta, DNACH
Target
FUNCTION: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SUBUNIT: Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Waldmann R, et al. J. Biol. Chem. 270:27411-27414(1995).
2. Ota T, et al. Nat. Genet. 36:40-45(2004).
3. Gregory S.G, et al. Nature 441:315-321(2006).
4. Giraldez,T, et al. J. Neurochem. 102 (4), 1304-1315 (2007).
5. Ji,H.L, et al. J. Biol. Chem. 281 (12), 8233-8241 (2006).
2. Ota T, et al. Nat. Genet. 36:40-45(2004).
3. Gregory S.G, et al. Nature 441:315-321(2006).
4. Giraldez,T, et al. J. Neurochem. 102 (4), 1304-1315 (2007).
5. Ji,H.L, et al. J. Biol. Chem. 281 (12), 8233-8241 (2006).
Limitation
For research use only
Code
OSR00100W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for SCNN1D.
Spcs X-react.
Human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Code
OSR00100W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to SCNN1D
