FIG4 antibody, SAC3 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSF00011W

$240USD

ID Tag

Rb1813-240612-WS

Immunogen

A synthetic peptide from aa region 700-800 of human FIG4 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

FIG4_HUMAN
FIG4_RAT
FIG4_MOUSE

Also known

Polyphosphoinositide phosphatase, Phosphatidylinositol 3,5-bisphosphate 5-phosphatase, SAC domain-containing protein 3

Target

The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide substrates in the order PtdIns(4,5)P2 > PtdIns(3,5)P2 > PtdIns(3,4,5)P3. Plays a role in the biogenesis of endosome carrier vesicles (ECV) / multivesicular bodies (MVB) transport intermediates from early endosomes.
Defects in FIG4 are the cause of Charcot-Marie-Tooth disease type 4J (CMT4J).
Defects in FIG4 are the cause of amyotrophic lateral sclerosis type 11 (ALS11).
SUBCELLULAR LOCATION: Endosome membrane. Note: Localization requires VAC14 and PIKFYVE.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Chow C.Y, et al. Nature 448:68-72(2007).
2. Sbrissa D, et al. J. Mol. Biol. 384:766-779(2008)

Limitation

For research use only

Code

OSF00011W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.

Specificity

Specific for FIG4.

Spcs X-react.

Human, rat. Other species not yet tested but expected to work in mouse.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSF00011W