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Code
OSF00008W
$240USD
ID Tag
Rb1771-260312-WS
Immunogen
A synthetic peptide from mature mouse Frataxin conjugated to blue carrier protein was used as the antigen.
Accession
Also known
Fxn, Fxn, Frda
Target
FunctionPromotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe2+ to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe2+ to Fe3+; the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization. Modulates the RNA-binding activity of ACO1.
SUBCELLULAR LOCATION: Cytoplasm By similarity. Mitochondrion. Note: reportedly, localizes exclusively in mitochondria.
Tissue specificity: Heart, liver, skeletal muscle, kidney, spleen and thymus. Weakly expressed in the brain and lung.
SUBCELLULAR LOCATION: Cytoplasm By similarity. Mitochondrion. Note: reportedly, localizes exclusively in mitochondria.
Tissue specificity: Heart, liver, skeletal muscle, kidney, spleen and thymus. Weakly expressed in the brain and lung.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Koutnikova H, et al. Nat. Genet. 16:345-351(1997)
Limitation
For research use only
Code
OSF00008W
$240USD
Unit size
100 ul
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user.
Specificity
Specific for Frataxin.
Spcs X-react.
Rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSF00008W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to Frataxin
