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Code
OSB00058W
$240USD    Buy Now 

ID Tag
Rb1637-211110-WS

Immunogen
A synthetic peptide from internal region of mouse Bestrophin 1 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

Also known
TU15B, Vitelliform macular dystrophy protein 2, BEST1, VMD2

Target
FUNCTION: Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.
Subcellular location: Cell membrane; Multi-pass membrane protein. Basolateral cell membrane
Tissue specificity: Predominantly expressed in the basolateral membrane of the retinal pigment epithelium.
Defects in BEST1 are the cause of vitelliform macular dystrophy type 2 (VMD2) also known as Best macular dystrophy (BMD). VMD2 is an autosomal dominant form of macular degeneration that usually begins in childhood or adolescence. VMD2 is characterized by typical 'egg-yolk' macular lesions due to abnormal accumulation of lipofuscin within and beneath the retinal pigment epithelium cells. Progression of the disease leads to destruction of the retinal pigment epithelium and vision loss.
Defects in BEST1 are the cause of retinitis pigmentosa type 50 (RP50).
Defects in BEST1 are a cause of adult-onset vitelliform macular dystrophy (AVMD).
Defects in BEST1 are the cause of bestrophinopathy autosomal recessive (ARB).
Defects in BEST1 are the cause of vitreoretinochoroidopathy autosomal dominant (ADVIRC).

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Kraemer F, et al. Cytogenet. Genome Res. 105:107-114(2004)
2. Petrukhin K, et al. Nat. Genet. 19:241-247(1998)

Limitation
For research use only

Code
OSB00058W
$240USD    Buy Now 

Unit size
100 µl

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
Whole serum

Clonality
Polyclonal

Isotype
Polyclonal, whole serum

Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for Bestrophin 1.

Spcs X-react.
Mouse. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

⚬ Products
Rabbit antibody to Bestrophin 1
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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