Rb1579-120910-WS

A synthetic peptide from internal region of mouse Ankyrin 2 (ANK2) conjugated to blue carrier protein was used as the antigen.

ANK2, ANK-2, Brain ankyrin

FUNCTION: Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.
Subcellular location: Cytoplasm › cytoskeleton. Membrane. Cytoplasm › myofibril › sarcomere › M-band. Apical cell membrane. Cell membrane. Note: Expressed at the apical membrane of airway lung epithelial cells. Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distict intracellular compartment of neonatal cardiomyocytes.
Tissue specificity: Present in skeletal muscle, kidney, lung, testes, spleen and lung. In the pancreas, highly expressed in islets and concentrated in beta cells. Expressed in Purkinje neurons in cerebellum. Expression in the central nerve tracts in forebrain and cerebellum is elevated in the myelinate-deficient strain Shiverer. Expressed in the inner segments of rod photoreceptors in retina.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Chan W, et al. J. Cell Biol. 123:1463-1473(1993)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 1000 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for ANK3.

Mouse. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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