A synthetic peptide from extracellular domain of human CD36 conjugated to blue carrier protein was used as the antigen.
Platelet glycoprotein 4, Platelet glycoprotein IV,GPIV, Glycoprotein IIIb, GPIIIB, Leukocyte differentiation antigen CD36, PAS IV, PAS-4, Platelet collagen receptor, Fatty acid translocase, FAT, Thrombospondin receptor, CD36, GP3B, GP4
FUNCTION: Seems to have numerous potential physiological functions. Recent compelling evidence from rodent and human studies raise the possibility for an additional sixth taste modality devoted to the perception of lipids. Recent studies strongly suggest that lingual CD36, being implicated in the perception of dietary fat, may act as a gustatory lipid sensor (1).
Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
Defects in CD36 are the cause of platelet glycoprotein IV deficiency; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Khan NA, et al. Biochim Biophys Acta. 2009 Jan 14.
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 1000 is recommended for IHC-P and 1:60000 for WB for human and marmoset is recommended. For rat and mouse a dilution of 1:10000 recommended for WB. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for CD36.
Human, marmoset, rat, mouse. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.