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Code
OSK00053W
$240USD    Buy Now 

ID Tag
Rb1942-281012-WS

Immunogen
A synthetic peptide from aa region 30-80 of human KCNJ6 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

Also known
G protein-activated inward rectifier potassium channel 2, GIRK2, Potassium channel, inwardly rectifying subfamily J member 6, Inward rectifier K(+) channel Kir3.2, KATP-2, BIR1, KATP2, KCNJ7

Target
FUNCTION: This potassium channel may be involved in the regulation of insulin secretion by glucose and/or neurotransmitters acting through G-protein-coupled receptors. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.
Tissue specificity: Most abundant in cerebellum, and to a lesser degree in islets and exocrine pancreas.
Subcellular location: Membrane, Multi-pass membrane protein.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Ferrer J, et al. J. Biol. Chem. 270:26086-26091(1995)
2. Schoots O, et al. Cell. Signal. 11:871-883(1999)
3. Sakura H, et al. FEBS Lett. 367:193-197(1995)
4. Tsaur M.-L, et al. Diabetes 44:592-596(1995)

Limitation
For research use only

Code
OSK00053W
$240USD    Buy Now 

Unit size
100 µl

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
Whole serum

Clonality
Polyclonal

Isotype
Polyclonal, whole serum

Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for KCNJ6.

Spcs X-react.
Human. Other species not yet tested but expected to work in rat and mouse.

Format
Lyophilised

Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

⚬ Products
Rabbit antibody to KCNJ6
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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