SHANK3 antibody, SHANK-3 antibody, SHANK 3 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSS00208W

$240USD

ID Tag

Gt201-101009-WS

Immunogen

A synthetic peptide from the internal region of human SHANK3 (SH3 and multiple ankyrin repeat domains protein 3, ProSAP2) conjugated to an immunogenic carrier protein was used as the antigen.

Accession

SHANK3_HUMAN
SHANK3_RAT
SHANK3_MOUSE

Also known

SH3 and multiple ankyrin repeat domains protein 3, ProSAP2, Proline rich synapse associated protein 2, PSAP2

Target

Function: Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Subcellular location: Cytoplasm. Cell junction âº synapse. Cell junction âº synapse âº postsynaptic cell membrane âº postsynaptic density. Note: Postsynaptic density of neuronal cells. Extends into the region subjacent to the PSD.
Tissue specificity: Widely expressed in brain.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Dunham I, et al. ature 402:489-495(1999)
2. Hirosawa M, et al. DNA Res. 8:1-9(2001)
3. Soltau M, et al. Mol. Cell. Neurosci. 21:575-583(2002)
4. Durand C.M, et al. Nat. Genet. 39:25-27(2007)
5. Zahedi R.P, et al. J. Proteome Res. 7:526-534(2008)

Limitation

For research use only

Code

OSS00208W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

Goat

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for SHANK3.

Spcs X-react.

Human, rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSS00208W