A synthetic peptide from aa region 30-100 of human Tyrosine Hydroxylase conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
TY3H, Tyrosine 3-monooxygenase, Tyrosine 3-hydroxylase, Tyrosine 3 hydroxylase, TH
Function: Plays an important role in the physiology of adrenergic neurons.
Defects in TH are the cause of dystonia DOPA-responsive autosomal recessive (ARDRD); also known as autosomal recessive Segawa syndrome. ARDRD is a form of DOPA-responsive dystonia presenting in infancy or early childhood. Dystonia is defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. Some cases of ARDRD present with parkinsonian symptoms in infancy. Unlike all other forms of dystonia, it is an eminently treatable condition, due to a favorable response to L-DOPA.
Subcellular location: Nucleus. Cytoplasm
Tissue specificity: Mainly expressed in the brain and adrenal glands.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Kaneda N, et al. Biochem. Biophys. Res. Commun. 146:971-975(1987)
2. Grima B, et al. Nature 326:707-711(1987)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for TH.
Human, rat, mouse. Other species not yet tested.
Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.