A synthetic peptide from aa region 595-645of human Synapsin 1 conjugated to blue carrier protein was used as the antigen.
Synapsin 1, Syn1, Synapsin I
May act as an anchoring protein by linking the vesicle phospholipid layer and the cytoskeleton in neuronal presynaptic terminals; may play a role in neurotransmitter release.
FUNCTION: Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior disorders. XELBD is characterized by variable combinations of epilepsy, learning difficulties, macrocephaly, and aggressive behavior.
SUBCELLULAR LOCATION: Cell junction, synapse. Golgi apparatus.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Ross M.T, et al. Nature 434:325-337(2005)
2. Matsuoka S, et al. Science 316:1160-1166(2007)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 2000 to 1 : 4000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for Synapsin-1.
Human, rat, mouse. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.