LATS1 antibody, WARTS antibody, Large tumor suppressor homolog 1 antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSL00008W

$240USD

ID Tag

Rb879-290309-WS

Immunogen

A synthetic peptide to the c-terminal of mouse LATS1 (WARTS) conjugated to an immunogenic carrier protein was used as the antigen.

Accession

LATS1_MOUSE
LATS1_RAT
LATS1_HUMAN

Also known

Serine/threonine-protein kinase LATS1, Large tumor suppressor homolog 1, WARTS protein kinase

Target

FUNCTION: Tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function.
Subcellular location: Centrosome, Spindle. Note: Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Carninci P, et al. Science 309:1559-1563(2005)
2. Tao W, et al. Nat. Genet. 21:177-181(1999)
3. St John M.A, et al. Nat. Genet. 21:182-186(1999)
4. Trost M, et al. Immunity 30:143-154(2009)

Limitation

For research use only

Code

OSL00008W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for LATS1.

Spcs X-react.

Mouse, rat. Other species not yet tested, but expected to work in human.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSL00008W