Rb938-240509-WS

A synthetic peptide from the internal region of human Sodium channel protein type 5 subunit alpha (SCN5A, Nav1.5) conjugated to an immunogenic carrier protein was used as the antigen.

Sodium channel protein type V subunit alpha, Voltage-gated sodium channel subunit alpha Nav1.5, Sodium channel protein cardiac muscle subunit alpha, HH1, SCN5A

FUNCTION: This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na⁺ ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na⁺ channel isoform. This channel is responsible for the initial upstroke of the action potential in the electrocardiogram.
Tissue specificity: Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Gellens M.E, et al. Proc. Natl. Acad. Sci. U.S.A. 89:554-558(1992)
2. Makielski J.C, et al. Circ. Res. 93:821-828(2003)
3. Ou S.-W, et al. Eur. J. Neurosci. 22:793-801(2005)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for SCN5A.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet