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Code
OSD00019G
$240USD    Buy Now 

ID Tag
Sh130-070309-G

Immunogen
A synthetic peptide from aa region 120-170 of human DCTN1 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat and moue.

Accession

Also known
DAP-150, DP-150, p150-glued,p135, Dynactin subunit 1, 150 kDa dynein-associated polypeptide

Target
FUNCTION: Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
SUBUNIT: Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein. Interacts with the C-terminus of MAPRE1, MAPRE2 and MAPRE3.
SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton.
TISSUE SPECIFICITY: Brain.
DISEASE: Defects in DCTN1 are the cause of progressive lower motor neuron disease. PLMND is a progressive dominant disease that has no sensory symptoms.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Collin G.B, et al. Genomics 53:359-364(1998).
2. Bu W, et al. J. Biol. Chem. 278:49721-49731(2003).

Limitation
For research use only

Related
products
 
Code Product Name
OSD00018W Sheep antibody to DCTN1
 

Code
OSD00019G
$240USD    Buy Now 

Unit size
500 µg

Conjugate
Unconjugated antibody

Host
Sheep

Purity
IgG

Clonality
Polyclonal

Isotype
Polyclonal, IgG

Applications
IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for DCTN1.

Spcs X-react.
Human, Mouse, rat. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.

Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

⚬ Products
Sheep antibody to DCTN1
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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