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Code
OSC00064W
$240USD
ID Tag
Sh110-060908-WS
Immunogen
A synthetic peptide to phospho S271 & S274 of human CREM (cAMP-responsive element modulator, Inducible cAMP early repressor, ICER) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in rat, mouse and dog.
Accession
Also known
cAMP-responsive element modulator, Inducible cAMP early repressor, ICER
Target
FUNCTION: Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation.
SUBUNIT: Binds DNA as a dimer. Interacts with FHL5.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
SUBUNIT: Binds DNA as a dimer. Interacts with FHL5.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Masquilier D, et al. Cell Growth Differ. 4:931-937(1993).
2. Nagamori I, et al. J. Biol. Chem. 281:15073-15081(2006).
2. Nagamori I, et al. J. Biol. Chem. 281:15073-15081(2006).
Limitation
For research use only
Code
OSC00064W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
Sheep
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. This antibody may also recognise the unphosphorylated form.
Specificity
Specific for CREM.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSC00064W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Sheep antibody to phospho S271 & S274 of CREM
