phospho Y816 of TrkB antibody, TrkB antibody, BDNF/NT-3 growth factors receptor antibody

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OST00220W

$260USD

ID Tag

Rb1471-120610-WS

Immunogen

A synthetic peptide from aa region 730-821 of rat TrkB conjugated to blue carrier protein was used as the antigen. The peptide is homologous in human and mouse.

Accession

TRKB_HUMAN
TRKB_RAT
TRKB_MOUSE

Also known

Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor

Target

FUNCTION: Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1.
CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20C for long term storage and refrigerated at 2-8C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Klein R, et al. EMBO J. 8:3701-3709(1989).

Limitation

For research use only

Related
products

Code	Product Name
OST00221G	Rabbit antibody to phospho Y816 of TrkB

Code

OST00220W

$260USD

Unit size

100 ul

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB. A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user.

Specificity

Specific for TrkB.

Spcs X-react.

Human, rat, mouse. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material.

Code

OST00220P

$120USD

ID Tag

54633-11

Unit size

50 Âµg

Accession

TRKB_HUMAN
TRKB_RAT
TRKB_MOUSE

Also known

Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB/GP95-TrkB, Trk-B, BDNF/NT-3 growth factors receptor

Target

This is the immunising peptide for the products Rabbit antibody to phospho Y816 of TrkB (OST00220W. OST00221G)

Purity

>85%

Applications

Control peptide

Format

Lyophilised

Reconstitution

This peptide is soluble in PBS and water.

Storage

Maintain refrigerated at 2-8°C for up to 12 months. After reconstitution keep at -20°C. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

Limitation

For research use only