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Code
OST00216W
$240USD    Buy Now 

ID Tag
Rb636-170808-WS

Immunogen
A synthetic peptide from the 1t extracellular loop of human TRPV5 conjugated to blue carrier protein was used as the antigen.
The location of the epitope is highlighted in green.

Accession

Also known
TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC, ECaC1, Calcium transport protein 2, CaT2, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5

Target
This gene is a member of the transient receptor family and the TrpV subfamily. The calcium-selective channel encoded by this gene has 6 transmembrane-spanning domains, multiple potential phosphorylation sites, an N-linked glycosylation site, and 5 ANK repeats. This protein forms homotetramers or heterotetramers and is activated by a low internal calcium level.
FUNCTION: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.
SUBCELLULAR LOCATION: Apical cell membrane; Multi-pass membrane protein. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells.
TISSUE SPECIFICITY: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Mueller D, et al. Genomics 67:48-53(2000).

Limitation
For research use only

Code
OST00216W
$240USD    Buy Now 

Unit size
100 µl

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
Whole serum

Clonality
Polyclonal

Isotype
Polyclonal, whole serum

Applications
IHC, WB. A dilution of 1 : 1000 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested iin other applications.

Specificity
Specific for TRPV5.

Spcs X-react.
Human. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Code
GST00037P
$120USD   

ID Tag
53756-23

Unit size
50 µg

Accession

Also known
TrpV5, osm-9-like TRP channel 3, OTRPC3, Epithelial calcium channel 1, ECaC, ECaC1, Calcium transport protein 2, CaT2, CAT2, ECAC1, OTRPC3, transient receptor potential cation channel subfamily V member 5

Target
This is the immunising peptide for the product Rabbit antibody to 1t extracellular loop of human TRPV5: whole serum (OST00216W).

Purity
>86%

Applications
Control peptide

Format
Lyophilised

Reconstitution
This peptide is soluble in PBS and water.

Storage
Maintain refrigerated at 2-8°C for up to 12 months. After reconstitution keep at -20°C. Avoid freeze and thaw cycles.

Expiry Date
12 months from the date of purchase

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

Limitation
For research use only

Related Products
OST00216W

⚬ Products
Rabbit antibody to TRPV5
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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