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Code
OSV00008W
$240USD
ID Tag
Sh89-290608-WS
Immunogen
A synthetic peptide from human Vesicle-associated membrane protein 2 conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many other species including rat, mouse and xenopus.
Accession
Also known
VAMP-2, Synaptobrevin-2, VAMP2, SYB2
Target
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note: Neuronal synaptic vesicles.
FUNCTION: Involved in the targeting and/or fusion of transport vesicles to their target membrane.
SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note: Neuronal synaptic vesicles.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Archer B.T, et al. J. Biol. Chem. 265:17267-17273(1990).
2. Jagadish M.N, et al. Biochem. J. 317:945-954(1996).
3. Kutay U, et al. EMBO J. 14:217-223(1995).
2. Jagadish M.N, et al. Biochem. J. 317:945-954(1996).
3. Kutay U, et al. EMBO J. 14:217-223(1995).
Limitation
For research use only
Related
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Code
OSV00008W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
Sheep
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for VAMP2.
Spcs X-react.
Human, rat, mouse. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSV00008W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Sheep antibody to VAMP2
