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Code
OSD00021G
$240USD    Buy Now 

ID Tag
Rb895-260409-G

Immunogen
A synthetic peptide from c-terminal region of mouse Desmin conjugated to an immunogenic carrier protein was used as the antigen. The antigen is homologous in human and rat.

Accession

Also known
Des

Target
Function: Desmin are class-III intermediate filaments found in muscle cells. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures.
Defects in DES are the cause of desmin-related cardio-skeletal myopathy (CSM); also known as desmin-related myopathy (DRM). CSM is characterized by skeletal muscle weakness associated with cardiac conduction blocks, arrhythmias, restrictive heart failure, and by intracytoplasmic accumulation of desmin-reactive deposits in cardiac and skeletal muscle cells. A desmin-related myopathy can have a distal onset, it is then known as hereditary distal myopathy (HDM).
Defects in DES are the cause of neurogenic scapuloperoneal syndrome Kaeser type (Kaeser syndrome).
Subcellular location: Cytoplasm.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Li Z, et al. Gene 78:243-254(1989)
2. Goldfarb L.G, et al. Nat. Genet. 19:402-403(1998)
3. Goudeau B, et al. Hum. Mutat. 18:388-396(2001)
4. Li H, et al. J. Cell Biol. 124:827-841(1994)
5. van Groningen J.J.M, et al. Biochim. Biophys. Acta 1217:107-109(1994)

Limitation
For research use only

Related
products
 
Code Product Name
OSD00020W Rabbit antibody to Desmin
 

Code
OSD00021G
$240USD    Buy Now 

Unit size
1000 µg

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
IgG

Clonality
Polyclonal

Isotype
Polyclonal, IgG

Applications
IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for Desmin.

Spcs X-react.
Mouse, human, rat. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 1000 µl of sterile water. Centrifuge to remove any insoluble material.

Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

⚬ Products
Rabbit antibody to Desmin
Content

Download Protocols

APES coating of slides
SDS Loading Buffer
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
.G6 Lysing Buffer
Content

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