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Code
OSM00018A
$240USD
ID Tag
ME20.4-131207-AP
Immunogen
Human melanoma cell lines
Accession
Also known
Tumor necrosis factor receptor superfamily member 16, P08138, low-affinity nerve growth factor receptor, NGF receptor, Gp80-LNGFR, p75 ICD, low affinity neurotrophin receptor p75NTR, CD271 antigen, NGFR, TNFRSF16
Target
FUNCTION: Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells.
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9. Interacts through TRAF6 with SQSTM1 which bridges NGFR to NTRK1. Interacts with BEX1 and NGFRAP1/BEX3.
SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Ross AH, et al. Proc Natl Acad Sci USA 81:6681-5(1984).
Limitation
For research use only
Related
products
products
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Code
OSM00018A
$240USD
Unit size
150 µg
Conjugate
Unconjugated antibody
Host
Mouse
Purity
Affinity purified
Clonality
Monoclonal
Isotype
IgG1
Applications
IHC, WB, FC. A concentration of 2-10 µg/ml is recommended. The optimal working concentration should be determined by the end user. This antibody may also be used for immunoabsorptive purification of NGF-receptors. See also the eLab Book at the end of this page.
Specificity
Specific for p75NTR.
Spcs X-react.
Human, marmoset, dog, cat, pig, rabbit
Format
Lyophilised
Reconstitution
Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSM00018A
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Mouse monoclonal antibody to p75NTR (ME20.4)
