A synthetic peptide aa region 50-100 of human 40S ribosomal protein SA conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Immature laminin receptor, nonintegrin laminin receptor precursor, 40S ribosomal protein SA, p40, 34/67 kDa laminin receptor, Colon carcinoma laminin-binding protein, NEM/1CHD4, Multidrug resistance-associated protein MGr1-Ag, LAMBR, LAMR1, RPSA ribosomal protein SA, LRP, 67LR, 37LRP
The expression of nonintegrin laminin receptor precursor protein on olfactory stem and progenitor cells has been reported by Schwob J, et al ( See ref. 6).
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Yow H, et al. Proc. Natl. Acad. Sci. U.S.A. 85:6394-6398(1988).
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 3000 is recommended for WB and 1:1000 for OHC-P. The optimal dilution should be determined by the end user.
Specific for 40S ribosomal protein SA
Rat, mouse, human. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.