GPCR GPR120 antibody, FFAR4 antibody, GPR129 antibody, PGR antibody4

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSG00105W

$240USD

ID Tag

Rb2396-170614-WS

Immunogen

A synthetic peptide from aa region 250-300 of human GPR120 conjugated to blue carrier protein was used as the antigen. The antigen shares 96% identity with mouse's sequence and 91% with rat's.

Accession

GPR120_HUMAN

Also known

Free fatty acid receptor 4, FFAR4, G protein coupled receptor 120, G protein coupled receptor 129, G protein coupled receptor GT01, G protein coupled receptor PGR4, Omega 3 fatty acid receptor 1, GPR129, O3FAR1, PGR4

Target

FUNCTION: Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti-inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage-induced tissue inflammation. May mediate the taste of fatty acids. Mediates FFA-induced inhibition of apoptosis in enteroendocrine cells. May play a role in the regulation of adipocyte development and differentiation.
SUBCELLULAR LOCATION: Cell membrane. Multi-pass membrane protein
Expression: Abundant expression in the intestinal tract. Highly expressed in adipose tissue, small intestine and pancreas.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Hirasawa A, et al. Nat. Med. 11:90-94(2005)

Limitation

For research use only

Code

OSG00105W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 1000 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for GPR120.

Spcs X-react.

Human. Other species not yet tested but expected to work in mouse and rat.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSG00105W