A synthetic peptide from aa region 1050-1100 of human AIP1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Membrane associated guanylate kinase, WW and PDZ domain containing protein 2, Atrophin 1 interacting protein 1, AIP-1, Atrophin 1 interacting protein A, Membrane-associated guanylate kinase inverted 2, MAGI-2, MAGI2, ACVRINP1
FUNCTION: Seems to act as scaffold molecule at synaptic junctions by assembling neurotransmitter receptors and cell adhesion proteins. May play a role in regulating activin-mediated signaling in neuronal cells. Enhances the ability of PTEN to suppress AKT1 activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth.
SUBCELLULAR LOCATION: Cytoplasm. Late endosome. Cell junction âº synapse âº synaptosome. Cell membrane; Peripheral membrane protein. Note: Localized diffusely in the cytoplasm before nerve growth factor (NGF) stimulation. Recruted to late endosomes after NGF stimulation. Membrane-associated in synaptosomes.
TISSUE SPECIFICITY: Specifically expressed in brain.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Wood J.D, et al. Mol. Cell. Neurosci. 11:149-160(1998)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for AIP1.
Human, rat, mouse. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.