⚬ Services
Code
OSC00309W
$240USD    Buy Now 

ID Tag
Rb2134-230713-WS

Immunogen
A synthetic peptide from aa region 60-110 of mouse CNGA1 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

Also known
CNGA1, cGMP-gated cation channel alpha-1, CNG-1, CNG1, Cyclic nucleotide-gated channel alpha-1, Cyclic nucleotide-gated channel, photoreceptor, Cyclic nucleotide-gated cation channel 1, Rod photoreceptor cGMP-gated channel subunit alpha, CNCG, CNCG1

Target
FUNCTION: Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cyclic GMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Defects in CNGA1 are a cause of retinitis pigmentosa autosomal recessive (ARRP). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
Subcellular location: Membrane; Multi-pass membrane protein.
Tissue specificity: Rod cells in the retina.

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Pittler S.J, et al. J. Biol. Chem. 267:6257-6262(1992)
2. Karlson K.H, et al. Biochim. Biophys. Acta 1236:197-200(1995)

Limitation
For research use only

Related
products

Code
OSC00309W
$240USD    Buy Now 

Unit size
100 µl

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
Whole serum

Clonality
Polyclonal

Isotype
Polyclonal, whole serum

Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for CNGA1.

Spcs X-react.
Mouse. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

⚬ Products
Rabbit antibody to CNGA1 (60-110)
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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