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Code
OSC00289W
$240USD
ID Tag
Rb2018-200213-WS
Immunogen
A synthetic peptide from aa region 50-100 of mouse CBX3 conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
Chromobox protein homolog 3, HECH, HP1 gamma
Target
FUNCTION: Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
SUBCELLULAR LOCATION: Nucleus Potential. Note: Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
SUBCELLULAR LOCATION: Nucleus Potential. Note: Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Koike N, et al. FEBS Lett. 467:17-21(2000)
2. Lee S.W, et al. J. Biol. Chem. 285:18-29(2010)
2. Lee S.W, et al. J. Biol. Chem. 285:18-29(2010)
Limitation
For research use only
Code
OSC00289W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for CBX3.
Spcs X-react.
Mouse, rat. Other species not yet tested but expected to work in human.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSC00289W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
⚬ Products
Rabbit antibody to CBX3
