A synthetic peptide from aa region 160-220 of rat FPR1 conjugated to an immunogenic carrier protein was used as the antigen.
fMet-Leu-Phe receptor, fMLP receptor, N-formyl peptide receptor, FPR, N formylpeptide chemoattractant receptor
FUNCTION: High affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein
TISSUE SPECIFICITY: Neutrophils
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Gao J.-L, et al. J. Biol. Chem. 268:25395-25401(1993)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for FPR1.
Rat. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.