GABA A Receptor gamma 2 antibody, Gabrg2 antibody

Primary Antibodies

Peptides

Histology / Detection

⚬ Services

OVERVIEW
SPECS
CONTROL PEPTIDE
MSDS/DS

Code

OSG00082W

$240USD

ID Tag

Rb1739-020111-WS

Immunogen

A synthetic peptide from aa region 10-100 of mouse GABA A Receptor gamma 2 conjugated to an immunogenic carrier protein was used as the antigen.

Accession

GBRG2_MOUSE
GBRG2_RAT
GBRG2_HUMAN

Also known

Gamma-aminobutyric acid receptor subunit gamma-2, GABA(A) receptor subunit gamma-2, Gabrg2, GBRG2, GABA A Receptor gamma 2 Gamma-aminobutyric acid receptor subunit delta, GABRD

Target

FUNCTION: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.
Defects in GABRG2 are the cause of childhood absence epilepsy type 2 (ECA2). Defects in GABRG2 are the cause of generalized epilepsy with febrile seizures plus type 3 (GEFS+3). Defects in GABRG2 are a cause of severe myoclonic epilepsy in infancy (SMEI).
SUBCELLULAR LOCATION: Cell junction âº synapse âº postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Storage

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date

12 months after reconstitution

Shipping

This item will be shipped to you at ambient temperature in a lyophilised form.

References

1. Pritchett D.B, et al. Nature 338:582-585(1989)
2. Khan Z.U, et al. J. Neurochem. 60:961-971(1993)

Limitation

For research use only

Code

OSG00082W

$240USD

Unit size

100 µl

Conjugate

Unconjugated antibody

Host

NZ white rabbit

Purity

Whole serum

Clonality

Polyclonal

Isotype

Polyclonal, whole serum

Applications

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity

Specific for GABRG2.

Spcs X-react.

Mouse, rat, human. Other species not yet tested.

Format

Lyophilised

Reconstitution

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

Code

OSG00082W