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Code
OSS00305W
$240USD
ID Tag
Rb1643-211110-WS
Immunogen
A synthetic peptide from human SLC39A4 conjugated to blue carrier protein was used as the antigen.
Accession
Also known
Solute carrier family 39 member 4, Zrt- and Irt-like protein 4, ZIP-4, SLC39A4, ZIP4
Target
FUNCTION: Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note: Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
TISSUE SPECIFICITY: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.
Involvement in disease: Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note: Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
TISSUE SPECIFICITY: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.
Involvement in disease: Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ). AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Kuery S, et al. Nat. Genet. 31:239-240(2002)
Limitation
For research use only
Code
OSS00305W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for SLC39A4.
Spcs X-react.
Human, rat. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
Code
OSS00305W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
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Rabbit antibody to SLC39A4
