A synthetic peptide from human SLC39A4 conjugated to blue carrier protein was used as the antigen.
Solute carrier family 39 member 4, Zrt- and Irt-like protein 4, ZIP-4, SLC39A4, ZIP4
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note: Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.
Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.
Involvement in disease: Defects in SLC39A4 are the cause of acrodermatitis enteropathica zinc-deficiency type (AEZ)
. AEZ is a rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. All these manifestations are reversible with zinc supplementation. Without zinc therapy this disease is fatal.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Kuery S, et al. Nat. Genet. 31:239-240(2002)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for SLC39A4.
Human, rat. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.