Rb1507-130810-WS

A synthetic peptide from c-terminal region of mouse Large neutral amino acids transporter small subunit 2 (SLC7A8, LAT2) conjugated to an immunogenic carrier protein was used as the antigen.

SLC7A8_MOUSE
SLC7A8_RAT

L-type amino acid transporter 2, Solute carrier family 7 member 8, LAT2, SLC7A8

FUNCTION: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
SUBCELLULAR LOCATION: Cytoplasm. Basolateral cell membrane; Multi-pass membrane protein. Note: Localized to the cytoplasm when expressed alone. When coexpressed with SLC3A2/4F2hc, is localized to the plasma membrane. Colocalized with SLC3A2/4F2hc at the basolateral membrane of kidney cortex proximal tubules and small intestine epithelia of the villi.
TISSUE SPECIFICITY: Strongly expressed in kidney and small intestine. Moderately present in placenta, ovary and brain

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Rossier G, et al. J. Biol. Chem. 274:34948-34954(1999)
2. Bassi M.T, et al. Genomics 62:297-303(1999)

For research use only

	Code Product Name OSS00266W Rabbit antibody to SLC7A8

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB (confirmed by recombinant protein). A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for SLC7A8.

Mouse. Other species not yet tested but likely to work in rat.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

- Click to download the Data Sheet

- Click to download the Material Safety Data Sheet