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Code
OSM00078W
$240USD    Buy Now 

ID Tag
Rb1211-051209-WS

Immunogen
A synthetic peptide from the n-terminal region of mouse Malcavernin (CCM2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in human and rat.

Accession

Also known
CCM2, Cerebral cavernous malformations protein 2 homolog, Osmosensing scaffold for MEKK3, Osm

Target
FUNCTION: May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock.
Subcellular location: Cytoplasm. Note: Treatment with sorbitol caused relocalization to ruffle-like structures.
Tissue specificity: Highly expressed in heart, lower expression in kidney, lung and liver (at protein level).

Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

Expiry Date
12 months after reconstitution

Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.

References
1. Uhlik M.T, et al. Nat. Cell Biol. 5:1104-1110(2003)
2. Carninci P, et al. Science 309:1559-1563(2005)
3. Church D.M, et al. PLoS Biol. 7:E1000112-E1000112(2009)

Limitation
For research use only

Code
OSM00078W
$240USD    Buy Now 

Unit size
100 µl

Conjugate
Unconjugated antibody

Host
NZ white rabbit

Purity
Whole serum

Clonality
Polyclonal

Isotype
Polyclonal, whole serum

Applications
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specificity
Specific for Malcavernin.

Spcs X-react.
Human, rat, mouse. Other species not yet tested.

Format
Lyophilised

Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

⚬ Products
Rabbit antibody to CCM2
Content

Download Protocols

APES coating of slides
Loading Buffer: Reducing
IHC-P on Autostainer
G1 Lysing Buffer
WB Protocol online
IHC-P HIER (Tris-EDTA, pH 9)
4% PFA
Davidson's fix (modified)
....Tissue lysate perparation
....G2 Lysing Buffer
....R Lysing Buffer
....G3 Lysing Buffer
....G4 Lysing Buffer
....G5 Lysing Buffer
....G6 Lysing Buffer
Content

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