Code
OSC00185W
$240USD
ID Tag
Rb1188-260909-WS
Immunogen
A synthetic peptide from 2d cytoplasmic domain of mouse Connexin-57 (CX57, CXA10) conjugated to an immunogenic carrier protein was used as the antigen.
Accession
Also known
CXA10, Gap junction alpha-10 protein, Connexin-57, Connexin57, Connexin 57, CX57, GJA10, Connexin 62
Target
FUNCTION: One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Involved in tracer coupling between horizontal cells of the retina. May play a role in the regulation of horizontal cell patterning.
Tissue specificity: Low levels were detected in skin, heart, kidney, testis, ovary, intestine. Expression not detected in brain, sciatic nerve or liver.
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Cell junction ⺠gap junction
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Manthey D, et al. J. Biol. Chem. 274:14716-14723(1999)
2. Church D.M, et al. PLoS Biol. 7:E1000112-E1000112(2009)
3. Hombach S, et al. Eur. J. Neurosci. 19:2633-2640(2004)
4. Soehl G, et al. Cell Commun. Adhes. 10:27-36(2003)
5. Ciolofan C, et al. Neuroscience 148:473-488(2007)
Limitation
For research use only
Code
OSC00185W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specificity
Specific for Connexin-57.
Spcs X-react.
Mouse. Other species not yet tested but expected to work in human.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.