A synthetic peptide from the c-terminal of human Alpha Synuclein (non-A beta component of AD amyloid) conjugated to an immunogenic carrier protein was used as the antigen.
Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, SNCA, NACP, PARK1
Function: May be involved in the regulation of dopamine release and transport. Soluble protein, normally localized primarily at the presynaptic region of axons, which can form filamentous aggregates that are the major non amyloid component of intracellular inclusions in several neurodegenerative diseases (synucleinopathies). Induces fibrillization of microtubule-associated protein tau. Reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation.
Subcellular location: Cytoplasm. Membrane. Nucleus. Note: Membrane-bound in dopaminergic neurons. Also found in the nucleus.
Tissue specificity: Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Okochi M, et al. J. Biol. Chem. 275:390-397(2000)
2. Choi W, et al. FEBS Lett. 576:363-368(2004)
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for Alpha Synuclein.
Human, rat, mouse. Other species not yet tested.
Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.