Rb954-280609-WS

A synthetic peptide from the n-terminal region of human Bardet Biedl syndrome 4 protein (BBS4) conjugated to an immunogenic carrier protein was used as the antigen.

BBS4

FUNCTION: May be required for the dynein-mediated transport of pericentriolar proteins to the centrosome. Required for microtubule anchoring at the centrosome but not for microtubule nucleation. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane.
SUBCELLULAR LOCATION: Centrosome. Cytoplasm › cytoskeleton. Cell projection › cilium membrane. Cytoplasm. Note: Localizes to the pericentriolar region throughout the cell cycle. Centrosomal localization requires dynein. Localizes to nonmembranous centriolar satellites in the cytoplasm.
TISSUE SPECIFICITY: Ubiquitously expressed. The highest level of expression is found in the kidney.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Mykytyn K, et al. Nat. Genet. 28:188-191(2001)
2. Ye X, et al. DNA Seq. 15:213-218(2004)
3. Katsanis N, et al. Am. J. Hum. Genet. 71:22-29(2002)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for BBS4.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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- Click to download the Material Safety Data Sheet