Rb906-260409-WS

A synthetic peptide from the n-terminal region of human KCNMB3 (Maxi K channel subunit beta-3) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.

Calcium-activated potassium channel subunit beta-3, Calcium-activated potassium channel, subfamily M subunit beta-3, Maxi K channel subunit beta-3, BK channel subunit beta-3, BKbeta3, Hbeta3, K(VCA)beta-3, Slo-beta-3, Charybdotoxin receptor subunit beta-3, KCNMBL

Function: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform, isoform and isoform partially inactivate the current of KCNBMA. Isoform induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer.
Tissue specificity: Isoform, isoform and isoform are widely expressed. Isoform is expressed placenta, pancreas, kidney and heart. Isoform and isoform are highly expressed in pancreas and testis.
Subcellular location: Membrane, Multi-pass membrane protein.

Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.

12 months after reconstitution

This item will be shipped to you at ambient temperature in a lyophilised form.

1. Riazi M.A, et al. Genomics 62:90-94(1999)
2. Zeng X.-H, et al. Nat. Struct. Biol. 10:448-454(2003)

For research use only

100 µl

Unconjugated antibody

NZ white rabbit

Whole serum

Polyclonal

Polyclonal, whole serum

IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.

Specific for KCNMB3.

Human. Other species not yet tested.

Lyophilised

Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.

Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com

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- Click to download the Material Safety Data Sheet