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Code
OSC00062W
$240USD
ID Tag
Rb694-060908-WS
Immunogen
A synthetic peptide from the n-terminal of human CHMP2A conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.
Accession
Also known
Chromatin-modifying protein 2a, Vacuolar protein-sorting-associated protein 2-1, Vps2-1, hVps2-1, Putative breast adenocarcinoma marker BC-2, BC2, Charged multivesicular body protein 2a
Target
FUNCTION: Component of the ESCRT-III complex, which is required for multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-III complex is probably involved in the concentration of MVB cargo. In case of infection, the HIV-1 virus takes advantage of the ESCRT-III complex for budding and exocytic cargos of viral proteins.
SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.
MISCELLANEOUS: Its overexpression strongly inhibits HIV-1 release.
SUBCELLULAR LOCATION: Late endosome membrane; Peripheral membrane protein; Cytoplasmic side.
MISCELLANEOUS: Its overexpression strongly inhibits HIV-1 release.
Storage
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date
12 months after reconstitution
Shipping
This item will be shipped to you at ambient temperature in a lyophilised form.
References
1. Kemmer D, et al. BMC Genomics 7:48-48(2006).
Limitation
For research use only
Code
OSC00062W
$240USD
Unit size
100 µl
Conjugate
Unconjugated antibody
Host
NZ white rabbit
Purity
Whole serum
Clonality
Polyclonal
Isotype
Polyclonal, whole serum
Applications
IHC, WB. A dilution of 1 : 1000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications.
Specificity
Specific for CHMP2A.
Spcs X-react.
Mouse, rat, human. Other species not yet tested.
Format
Lyophilised
Reconstitution
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Note
Control peptide is available at $120 per 50 μg. Please enquire sales@osenses.com
- Click to see the eLab Book
Code
OSC00062W
$240USD
PDF Data Sheet
- Click to download the Data SheetMSDS
Code
OSC00062W
$240USD
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WB on mouse tissue lysate. Blocking: 1% LFDM for 30 min at RT; primary antibody: dilution 1:1000 incubated at 4C overnight. Click on eLAB BOOK tab to see the details. |
⚬ Products
Rabbit antibody to CHMP2A
