A synthetic peptide from mouse Mucolipin 3 conjugated to blue carrier protein was used as the antigen.
MCLN3, Mcoln3 mucolipin 3, Va, TRPML3, TRP-ML3
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Expressed in the cochlea; particularly in the inner and outer hair cells.
DISEASE: Defects in Mcoln3 are the cause of the varitin-waddler (Va) phenotype. Classical Va mice exhibit early-onset hearing loss, vestibular defects, pigmentation abnormalities and perinatal lethality. The phenotype varitin-waddler Jackcon (Va-J), which arose in a cross segregating for Va, is similar but less severe.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Ota T, et al. Nat. Genet. 36:40-45(2004).
2. Gregory S.G, et al. Nature 441:315-321(2006).
For research use only
NZ white rabbit
Polyclonal, whole serum
IHC, WB. A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user.
Specific for Mucolipin 3.
Mouse, rat. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.