Sheep antibody to human, chicken microtubule-associated protein 1 light chain 3 beta (MAP1A/MAP1B LC3 B, Map1lc3b): whole serum

$240USD

Code	OSM00027W
ID Tag	Sh61-270108-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	150 µl
Immunogen	A synthetic peptide as a part of human, chicken microtubule-associated proteins 1A/1B light chain 3B (MAP1A/MAP1B LC3 B, Map1lc3b) conjugated to an immunogenic carrier protein has been used as the immunogen.
Conjugate	Unconjugated antibody
Accession	MAP1LC3B_HUMAN MAP1LC3B_CHICKEN
Also known as	MLP3B, Map1alc3, Map1lc3, Microtubule-associated protein 1 light chain 3 beta, MAP1A/MAP1B LC3 B, MAP1A/1B light chain 3 B, MAP1 light chain 3-like protein 2, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, Mpl3, MGC93422
Background	Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. FUNCTION: Probably involved in formation of autophagosomal vacuoles (autophagosomes). May mediate MAPlA and MAPlB microtubule binding activity during development of the nervous system SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor.Note: LC3-II binds to the autophagic membranes.
Host	Sheep
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. Use at a dilution of 1 : 200 to 1 : 3000. The optimal dilution should be determined by the end user.
Specificity	Specific for MAP1LC3B.
Spcs X-react.	Human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 150 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Stelzl U, et al. Cell 122 (6), 957-968(2005). 2. Tanida I, et al. Int. J. Biochem. Cell Biol. 36 (12), 2503-2518(2004). 3. Tanida I, et al. J. Biol. Chem. 279 (46), 47704-47710(2004). 4. Wiemann S, et al. Genome Res. 14 (10B), 2136-2144(2004). 5. He H, et al. J. Biol. Chem. 278 (31), 29278-29287(2003).
Limitation	For research use only

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Associated Products

Code	Product Name
OSM00025W	Rabbit antibody to rat, mouse microtubule-associated protein 1 light chain 3 beta (MAP1A/MAP1B LC3 B, Map1lc3b): whole serum
OSM00026W	Rabbit antibody to human, chicken microtubule-associated protein 1 light chain 3 beta (MAP1A/MAP1B LC3 B, Map1lc3b): whole serum