| Code |
OSC00011G |
| ID Tag |
Sh15-281007-G |
| Ordering info |
Order online using the shopping cart ("Add to Cooler"), by email to
sales@osenses.com
or fax to 61-8-827 0 8586 and pay via PayPal by
MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors.
This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
 |
| Unit size |
500 µg |
| Immunogen |
A synthetic peptide from human cFos protein conjugated to an immunogenic carrier protein has been used as the immunogen. The antigen is homologous in many species including rat, mouse, hamster and cat. |
| Conjugate |
Unconjugated antibody |
| Accession |
cFOS_HUMAN
cFOS_RAT
cFOS_MOUSE
cFOS_hamster
cFos_cat |
| Also known as |
Proto-oncogene protein cFOS |
| Background |
FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation.
SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB
SUBCELLULAR LOCATION: Nucleus.
INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury.
SIMILARITY: Belongs to the bZIP family. Fos subfamily
SIMILARITY: Contains 1 bZIP domain |
| Host |
Sheep |
| Purity |
IgG |
| Clonality |
Polyclonal |
| Isotype |
IgG |
| Applications |
IHC, WB. Use at a concentration of 10-50 µg/ml. The optimal working concentration should be determined by the end user. Not yet tested in other applications. |
| Specificity |
Specific for cFos. |
| Spcs X-react. |
Human, rat, mouse. Other species not yet tested. |
| Format |
Lyophilised |
| Reconstitution |
Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage |
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Expiry Date |
12 months after reconstitution |
| Transportation |
This item will be shipped to you at ambient temperature in a lyophilised form. |
| References |
1. van Straaten F, et al. Proc. Natl. Acad. Sci. U.S.A. 80:3183-3187(1983).
2. Hai T, et al. Genes Dev. 3:2083-2090(1989).
3. Heilig R, et al. Nature 421:601-607(2003).
4. Roux P, et al. Oncogene 6:2155-2160(1991).
5. Nakabeppu Y, et al. EMBO J. 8:3833-3841(1989).
6. Glover J.N, et al. Nature 373:257-261(1995).
7. Roux P, et al. Oncogene 6:2155-2160(1991).
8. Vasilescu J, et al. J. Proteome Res. 6:298-305(2007). |
| Limitation |
For research use only |
Primary Antibodies 
