Synthetic peptides from human Arg3.1 (ARC) was used as the immunogen. The antigen is homologous in rat and mouse.
Also known as
Activity-regulated cytoskeleton-associated protein, Activity-regulated gene 3.1 protein homolog, KIAA0278, Arg3.1/ARC,
FUNCTION: Required for consolidation of synaptic plasticity as well as formation of long-term memory. Regulates endocytosis of AMPA receptors in response to synaptic activity. Required for homeostatic synaptic scaling of AMPA receptors.
SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Endosome. Acrosome. Cell junction, synapse, postsynaptic cell membrane, postsynaptic density. Cell projection, dendrite. Cell projection, dendritic spine. Cell junction, synapse. Note: associated with the cell cortex of neuronal soma and dendrites. Enriched in postsynaptic density of dendritic spines. Associated with the sperm tail.
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
12 months after reconstitution
This item will be shipped to you at ambient temperature in a lyophilised form.
1. Tan J, et al. Neuroscience. 16;145(2):715-26(2007).
2. Link,W, et al. Proc. Natl. Acad. Sci. U.S.A. 92 (12), 5734-5738 (1995).
3. Shepherd J.D, et al. Neuron 52:475-484(2006).
4. Rial Verde E.M, et al. Neuron 52:461-474(2006).
5. Chowdhury S, et al. Neuron 52:445-459(2006).
For research use only
Polyclonal, whole serum
IHC, WB (confirmed by recombinant protein). A dilution of 1: 300 to 1: 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications.
Specific for Arg3.1/ARC.
Human, mouse and rat. Other species not yet tested.
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.