Rabbit antibody to Ras-related protein Ral-A (Rala, Ral, Ral-a): whole serum

$240USD

Code	OSR00268W
ID Tag	Rb325-200308-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide as a part of human, rat, mouse Ras-related protein Ral-A (Rala, Ral, Ral-a) conjugated to an immunogenic carrier protein was used as the immunogen.
Conjugate	Unconjugated antibody
Accession	RALA_HUMAN RALA_RAT RALA_MOUSE
Also known as	Rala, Ral, Ral-a, MGC48949
Background	The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding proteins mediate the transmembrane signaling initiated by the occupancy of certain cell surface receptors. This gene encodes a low molecular mass ras-like GTP-binding protein that shares about 50% similarity with other ras proteins. SUBUNIT: Interacts with RALBP1 via its effector domain. Interacts with EXOC8 and EXOC2. EXOC2 and EXOC8 have overlapping binding sites and compete for RALA binding. Interacts with Clostridium exoenzyme C3. Interacts with RALGPS1. SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor; Cytoplasmic side.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user.
Specificity	Appears to be specific for Ral-A.
Spcs X-react.	Human, rat, mouse. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Chardin P, et al. Nucleic Acids Res. 17:4380-4380(1989). 2. Polakis P.G, et al. J. Biol. Chem. 264:16383-16389(1989). 3. Hillier L.W, et al. Nature 424:157-164(2003). 4. Kinsella B.T, et al. J. Biol. Chem. 266:9786-9794(1991). 5. Holbourn K.P, et al. Proc. Natl. Acad. Sci. U.S.A. 102:5357-5362(2005). 6. Wildey G.M, et al. Biochem. Biophys. Res. Commun. 194:552-559(1993). 7. Cantor S.B, et al. Mol. Cell. Biol. 15:4578-4584(1995). 8. Park S.-H, et al. Oncogene 11:2349-2355(1995). 9. Zhao Z, et al. Mech. Dev. 97:201-204(2000).
Limitation	For research use only

IHC on rat brain (cortex) using Rabbit antibody to Ras-related protein Ral-A (Rala, Ral, Ral-a): whole serum (OSR00268W) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

IHC on rat septum using Rabbit antibody to Ras-related protein Ral-A (Rala, Ral, Ral-a): whole serum (OSR00268W) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

IHC on rat spinal cord (dorsal horn) using Rabbit antibody to Ras-related protein Ral-A (Rala, Ral, Ral-a): whole serum (OSR00268W) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

IHC on rat brain (striatum) using Rabbit antibody to Ras-related protein Ral-A (Rala, Ral, Ral-a): whole serum (OSR00268W) at 1 : 1000 dilution. Pre-absorption of the antibody with the immunising peptide completely abolishes the immunostaining (not shown).

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