phospho Y820 TrkC antibody

Rabbit antibody to phospho Y820 TrkC (Trk-C, NTRK3, NT-3 growth factor receptor, GP145-TrkC): whole serum

$240USD

Code	OST00233W
ID Tag	Rb679-060908-WS
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	100 µl
Immunogen	A synthetic peptide to phospho Y820 of human TrkC (Trk-C, NTRK3, NT-3 growth factor receptor, GP145-TrkC) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
Conjugate	Unconjugated antibody
Accession	TRKC_HUMAN TRKC_RAT TRKC_MOUSE
Also known as	Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3
Background	FUNCTION: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain.
Host	NZ white rabbit
Purity	Whole serum
Clonality	Polyclonal
Isotype	Polyclonal, whole serum
Applications	IHC, WB. A dilution of 1 : 300 to 1 : 3000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. This antibody may also recognise the unphosphorylated form.
Specificity	Specific for TrkC.
Spcs X-react.	Rat, mouse, human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Merlio J.P, et al. Neuroscience 51:513-532(1992). 2. Valenzuela D.M, et al. Neuron 10:963-974(1993). 3. Tsoulfas P, et al. Neuron 10:975-990(1993). 4. Qian X, et al. Neuron 21:1017-1029(1998). 5. Ballif B.A, et al. J. Proteome Res. 7:311-318(2008). 6. McGregor L.M, et al. Genomics 22:267-272(1994). 7. Shelton D.L, et al. J. Neurosci. 15:477-491(1995). 8. Ultsch M.H, et al. J. Mol. Biol. 290:149-159(1999).
Limitation	For research use only

WB on rat brain lysate using Rabbit antibody to phospho Y820 TrkC (Trk-C, NTRK3, NT-3 growth factor receptor, GP145-TrkC): whole serum (OST00233W) at 1 : 1000 dilution incubated overnight at 4°C. A single band will be detected. Pre-absorption of the antibody with the immunising peptide completely abolishes the detected band.

PDF Data Sheet	- Click to download the Data Sheet
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Associated Products

Code	Product Name
OST00234G	Rabbit antibody to phospho Y820 TrkC (Trk-C, NTRK3, NT-3 growth factor receptor, GP145-TrkC): IgG