Erk1, Erk2 antibody, phospho Erk1 and Erk2 antibody

Rabbit antibody to phospho T202 & Y204 Erk1, Erk2 (Mitogen-activated protein kinase 1 & 3, MAP kinase 1 & 2): IgG

$240USD

Code	OSE00010G
ID Tag	Rb706-060908-G
Ordering info	Order online using the shopping cart ("Add to Cooler"), by email to sales@osenses.com or fax to 61-8-827 0 8586 and pay via PayPal by MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors. This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
Unit size	500 µg
Immunogen	A synthetic peptide from the phospho T202 & Y204 of human Erk1, Erk2 (Mitogen-activated protein kinase 1 & 3, MAP kinase 1 & 2) conjugated to an immunogenic carrier protein was used as the antigen. The peptide is homologous in many species including rat, mouse, zebra fish, xenopus and chicken.
Conjugate	Unconjugated antibody
Accession	Erk1_HUMAN Erk2_HUMAN
Also known as	Mitogen-activated protein kinase 3, Extracellular signal-regulated kinase 1, Insulin-stimulated MAP2 kinase, MAP kinase 1, MAPK 1, p44-ERK1, ERT2, p44-MAPK, Microtubule-associated protein 2 kinase, Mitogen-activated protein kinase 1, Extracellular signal-regulated kinase 2, ERK-2, Mitogen-activated protein kinase 2, MAP kinase 2, MAPK 2, p42-MAPK, ERT1, MAPK1, PRKM1, PRKM2, MAPK3, PRKM3
Background	FUNCTION: Involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as ELK-1. Phosphorylates EIF4EBP1; required for initiation of translation. Phosphorylates microtubule-associated protein 2 (MAP2). Phosphorylates SPZ1. Phosphorylates heat shock factor protein 4 (HSF4). CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Activated by tyrosine phosphorylation in response to insulin and NGF. SUBUNIT: Interacts with MORG1. Binds to HIV-1 Nef. This interaction inhibits its kinase activity. Interacts with HSF4 and NISCH.
Host	NZ white rabbit
Purity	IgG
Clonality	Polyclonal
Isotype	Polyclonal, IgG
Applications	IHC, WB. A concentration of 10-50 µg/ml is recommended. The optimal concentration should be determined by the end user. This antibody may also recognise the unphosphorylated form. Not yet tested in other applications.
Specificity	Specific for Erk1 and Erk2.
Spcs X-react.	Mouse, rat, human. Other species not yet tested.
Format	Lyophilised
Reconstitution	Reconstitute in 500 µl of sterile water. Centrifuge to remove any insoluble material.
Storage	Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles.
Expiry Date	12 months after reconstitution
Transportation	This item will be shipped to you at ambient temperature in a lyophilised form.
References	1. Charest D.L, et al. Mol. Cell. Biol. 13:4679-4690(1993). 2. Zhang Y, et al. Mol. Cell. Proteomics 4:1240-1250(2005). 3. Rikova K, et al. Cell 131:1190-1203(2007). 4. Olsen J.V, et al. Cell 127:635-648(2006). 5. Wissing J, et al. Mol. Cell. Proteomics 6:537-547(2007).
Limitation	For research use only

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Associated Products

Code	Product Name
OSE00009W	Rabbit antibody to phospho T202 & Y204 Erk1, Erk2 (Mitogen-activated protein kinase 1 & 3, MAP kinase 1 & 2): whole serum