| Code |
OST00288W |
| ID Tag |
Rb886-290309-WS |
| Ordering info |
Order online using the shopping cart ("Add to Cooler"), by email to
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or fax to 61-8-827 0 8586 and pay via PayPal by
MasterCard or Visa. You can also provide us with your Purchase Order Number (PON) and pay by check or wire transfer. Alternatively contact our distributors.
This item is in our stock. The handling & shipping cost is $48 USD and the expected delivery time is within 5 business days worldwide.
 |
| Unit size |
100 µl |
| Immunogen |
A synthetic peptide from n-terminal region of human Transferrin receptor protein 1 (CD71, TfR, TR, p90) conjugated to an immunogenic carrier protein was used as the antigen. |
| Conjugate |
Unconjugated antibody |
| Accession |
TFR1_HUMAN |
| Also known as |
CD71, TfR, TR, p90, T9, Transferrin receptor |
| Background |
Function: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.
Serum transferrin receptor (sTfR) is used as a means of detecting erythropoietin (EPO) misuse by athletes and as a diagnostic test for anemia resulting from a number of conditions including rheumatoid arthritis, pregnancy, irritable bowel syndrome and in HIV patients.Canine and feline parvoviruses bind human and feline transferrin receptors and use these receptors to enter and infect cells.
Subcellular location: Cell membrane; Single-pass type II membrane protein. Melanosome. |
| Host |
NZ white rabbit |
| Purity |
Whole serum |
| Clonality |
Polyclonal |
| Isotype |
Polyclonal, whole serum |
| Applications |
IHC, WB. A dilution of 1 : 300 to 1 : 2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Specificity |
Specific for Transferrin receptor. |
| Spcs X-react. |
Human. Other species not yet tested. |
| Format |
Lyophilised |
| Reconstitution |
Reconstitute in 100 µl of sterile water. Centrifuge to remove any insoluble material. |
| Storage |
Maintain the lyophilised/reconstituted antibodies frozen at -20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Expiry Date |
12 months after reconstitution |
| Transportation |
This item will be shipped to you at ambient temperature in a lyophilised form. |
| References |
1. Schneider C, et al. Nature 311:675-678(1984)
2. McClelland A, et al. Cell 39:267-274(1984)
3. Baynes R.D, et al. Proc. Soc. Exp. Biol. Med. 197:416-423(1991)
4. Chicz R.M, et al. Nature 358:764-768(1992)
5. Douabin-Gicquel V, et al. Hum. Genet. 109:393-401(2001) |
| Limitation |
For research use only |
Primary Antibodies 
